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-  Members of Chinese Academy of  
- Members of Chinese Academy of Engineering 
- Changjiang Chair Professors 

 
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Members of Chinese Academy of Engineering

Daiming FAN

Professor Daiming Fan is the academician and vice president of Chinese Academy of Engineering, past president of Fourth Military Medical University, director of State Key Laboratory of Cancer Biology. He plays an important role in the national decision and administration of medical education, health care, and scientific research.

Professor Fan is now the president of Chinese Society of Gastroenterology, vice president of Chinese Anti-Cancer Association, council member and secretary general of Asian Pacific Association of Gastroenterology, awardee of Chang Jiang Scholars Program, a chief scientist of National Basic Research Program of China (973 Program). He is the president of World Congress of Gastroenterology (GASTRO2013) and Asian Pacific Digestive Week to be held in Shanghai in 2013.

He has a long-standing interest in both the clinical and basic research of digestive diseases, and has achieved a grand success especially in the study of gastric cancer. He has obtained a lot of national grants, including National Hi-tech Research and Development Program of China (863 Program), National Basic Research Program of China (973 Program) and Key Program of National Natural Science Fund, etc. He has won the first, second and third-class prizes of National Science and Technology Progress Awards respectively, and a third-class prize of National Technology Invention Awards. As an editor-in-chief he has authored 15 books on Gastroenterology and Oncology. As the first or corresponding author he has published more than three hundred papers in Nat Clin Pract Oncol, Lancet, JAMA, Ann Intern Med, Hepatology, Gut, Plos Genet, Ann Surg, J Hepatol, Faseb J, Clin Cancer Res, J Biol Chem, etc. He has become the Editor or Associate Editor of 7 international medical journals. 

 

                                                                   Zhinan CHEN

Zhinan CHEN (born in Yixing, Jiangsu Province) graduated from the Fourth Military Medical University with M. D. and Ph. D. degrees. He was elected academician of National Academy of Engineering in 2007. As an expert in cancer cell biology and biopharmaceuticals, he is currently the Director of Cell Engineering Research Center at the Fourth Military Medical University, a National Key Discipline of Cell Biology, and the Principal Investigator in the laboratory of antibody engineering & affinity proteomics, a State key Laboratory of Cancer Biology. He also serves as Chairman of the Committee of Cell Engineering & Transgenic Organism, Chinese Society of Cell Biology (CSCB); Commissioner of Chinese Society of Tumor Marker Oncology, Chinese Anti-Cancer Association; Vice Commissioner of Committee of Biochemistry & Biopharmaceutical, Chinese Pharmaceutical Association; a member of Consulting Committee for National Biology Industry Development; and Chief Research Officer of Vaccine and Antibody Engineering Project, a key project in Hi-Tech Research and Development Program of China.

Professor CHEN has been engaged in the field of biopharmaceuticals particularly in cancer cell biology, antibody engineering and cell engineering. He has successfully developed Iodine (131I) Metuximab Injection (LICARTINTM), a new biological with sole independent intellectual property right. He is the first to have proposed that HAb18G/CD147 is the target of LICARTIN and to have resolved the crystal structure of the extracellular portion of HAb18G/CD147, which is of great significance for the research and development of noval anti-tumor drugs. He has obtained 11 national patents for invention and 2 copyright-protected software products and is applying for 4 PCT patents. His work has resulted in 53 publications in SCI journals and earned him numerous awards, including the second prize of the National Award for the Advancements in Science and Technology, the first prize of the Shaanxi Provincial Award for Science and Technology Progress, and the first prize of the PLA Award for Advancements in Science and Technology.

Contact:

Tel:   86-29-84773243

ADDRESS:    Cell Engineering Research Center

  The Fourth Military Medical University

 17 Changle West Road, Xi'an 710032   P. R. of China

 


 Shengyong ZHANG

Prof. Shengyong Zhang (1939.11-) is the academician of National Academy of Engineering. He is a teacher of chemistry for Fudan university and the Fourth Military Medical University, respectively. Currently he is a professor and a Ph.D. supervisor in the Fourth Military Medical University. Prof. Zhang has trained 27 Ph.D. and M.S.,and he got numerous National and Military honors for his outstanding work for education.

Prof. Zhang has served as the member of the Chinese Chemical Society Committee and being the deputy director of Shaanxi Branch of the Chinese Chemical Society Member. Prof. Zhang is now the standing committee of the Military Medical Science and Technology Committee, vice president of Shaanxi Provincial Light Industry Association. Meanwhile he has been invited as a Visiting Professor for the Institute of “Chiral Drugs National Engineering Research Center”, as well as a Honor Professor at Northwest University and Shaanxi Normal University.

Research Interests

1.    Asymmetric Catalysis

2.    Synthesis of chiral drugs

3.    Resolution of racemic compounds

4.    Analysis,separation and determination of optical purity of chiral compounds.

Main achievement

So far from 1979 the chiral catalyst has been engaged in research, for example the design and synthesis of chiral ligands and chiral catalyst, and the asymmetric catalytic reactions. A number of key issues had been work out.

1.     Two new synthetic methods on chiral phosphine ligands were established, which were based on the stereoselective Diels-Alder reaction and nucleophilic addition of chiral epoxides.

2.     By introducing the –OH,-SO2- or any other polar group to cinchona alkaloid nuclear, a group of recyclable and reusable cinchona alkaloid derivatived ligands for Sharpless AD reaction was prepared. Via the ion- exchange technology bonding OsO4 to TentaGel resin, the recyclable and reusable catalyst TentaGel-OsO4 for AD reaction was obtained.

3.     Novel chiral ligands based on cinchona alkaloids and their Rh and Ir complexes were designed and prepared, which were successfully used in the asymmetric hydrogen transfer reaction of prochiral ketones, resulted in up to 93% yield and 97% ee.

4.     A group of new cinchona alkaloids ammonium salts were synthesized. And they have been successfully used in asymmetric phase-transfer catalysis and obtained up to 96% ee.

5.     A series of new cinchona alkaloids catalysts were designed and synthesized in asymmetric “interrupted” Feist-Benary reaction, which got up to 91% yield and 94% ee.

6.     D-phe, L-phe, anti-cancer drug taxol and docetaxel were first synthesized in an industrial scale by chiral catalysis in China.This work has made important contributions to improve the technologies of producing chemical pharmaceuticals and fine chemicals of China.

Awards and honors

1.    The gold prize of scientific and technological progress of the army’s (1997, first author)

2.    The bronze prize of State Technological Invention (1999, first author)

3.    The gold prize of technological progress in Shaanxi Province (2004, first author )

4.    The gold prize of technological progress in Shaanxi Province (2007, first author)

5.    Science and Technology Development Foundation of China issued the “Drug Development Award” (2000)

6.    “the Ninth Five-Year Plan ”army’s logistics major scientific achievement award (2000)

7.    The entire army outstanding teachers (2004)

8.    The national outstanding science and technology workers (2005)

9.    The national honourable teachers (2006)

10.  Enjoying the Government Special Allowances

Publications & Books

Published 4 monographs, such as 《Asymmetric Catalysis》,《Asymmetric Catalysis: new concepts and methods》,《Organometallic chemistry 》; 5 patents in China; 153 papers (of which 69 were included by SCI, 11 was included by EI).

8 textbooks, such as《Organic Chemistry》(editor-in-chief), 《Experiment Organic Chemistry》(joined editor) were published. 《Organic Chemistry》got the first and second prize of Excellent Teaching Materials by the State Education Commission.

Fourth Military Medical University 
No.169,Changle West Road,Xi'an,Shaanxi,710032,P.R.China