Feng GAO, M.D. Ph.D.
Feng GAO, born in 1962, graduated from the Fourth Military Medical University in 1985. He had his postdoctoral training in the field of ischemic heart disease at Thomas Jefferson University and Institute of Cardiovascular Research, Allegheney University in the United States. Since his return to the Fourth Military Medical University in 2002, he has focused on the study of insulin in cardioprotection and was awarded National Science Fund for Outstanding Young Scholars of China in 2006. He is currently a Cheung Kong Chair Professor of Medicine (Cheung Kong Scholar Program) at the Fourth Military Medical University and an adjunct professor of Peking University. He is also on the editorial board of Cardiovascular Research and Apoptosis.
Research Interests: He has been working in the field of cardiovascular protection with special emphasis on the role of insulin in cardiovascular health and disease and its underlying mechanisms. He has found that insulin, in addition to the metabolic modulation, exerts significant antiapoptotic and cardioprotective effects on the ischemic/reperfused heart by activating cardiac endogenous eNOS-NO system through PI3 kinase-Akt signaling pathway. This insulin-induced "survival" signaling and resultant cardioprotection may provide a novel approach to the development of pharmacological strategies for cardioprotection and the prevention of insulin resistance.
Research Grants (2002-):
1. National Science Fund for Outstanding Young Scholars of China (No.30625033), 2007-2010. (P.I.)
Title: Insulin triggered cell survival signaling in cardioprotection and cardiac insulin resistance
2. National Basic Research Program of China (973 Program) (No.2007CB512106), 2007-2011. (P.I.)
Title: Cardiac protection and its mechanisms of actions
3. Joint Research Fund for Overseas Chinese Young Scholars, National Natural Science Foundation of China (No.30728023), 2008-2011. (Co-P.I.)
Title: IGF-1-induced eNOS re-coupling and its role in diabetic cardiomyopathy
4. Outstanding Young Scholar Grant of Chinese Military Service (No. 06J014), 2006-2008. (P.I.)
Title: Insulin triggered cell survival signaling in cardiovascular protection
5. National Grant from National Natural Science Foundation of China (No.39970302), 2000-2002. (P.I.)
Title: “Ischemic postconditioning” protects ischemic myocardium from reperfusion injury
6. National Grant from National Natural Science Foundation of China (No.30370525), 2004-2006. (P.I.)
Title: Insulin-induced anti-apoptotic effect via Akt-NO survival signaling pathway in myocardial ischemia and reperfusion
7. National Grant from National Natural Science Foundation of China (No.30471923), 2005-2007. (P.I.)
Title: Mechanism of chronic aerobic exercise in improving myocardial sensitivity to insulin in young and aging subjects
8. National Grant from National Natural Science Foundation of China (No.30872718), 2009-2011. (P.I.)
Title: Malfunction of eNOS-mitochondrial translocation induces myocardial insulin resistance in aging rats
Selected Publications ( 2002 -, *Corresponding author ):
1. Li J, Zhang HF, Wu F, Nan Y, Ma H, Guo WY, Wang HC, Das UN, Gao F*. Suppression of TNF –α induction by insulin in the ischemic/reperfused rat hearts: Roles of Akt and eNOS phosphorylation. J Crit Care Med 2008; 36:1551-58.
2. Zhang HF, Li J, Li R, Zhang QJ, Ma H, Ji QH, Guo WY, Wang HC, Gao F*. Insulin resistance in cardiomyocytes of spontaneously hypertensive rats and its signaling mechanisms. J Hypertension 2008; 26:560-69.
3. Yu QJ, Si R, Zhou N, Zhang HF, Guo WY, Wang HC, Gao F*. Insulin inhibits b-adrenergic action in ischemic/reperfused heart: A novel mechanism of insulin in cardioprotection. Apoptosis. 2008; 13:305-17.
4. Zhang QJ, Li QX, Zhang HF, Zhang KR, Guo WY, Wang HC, Fan M, Zhou Z, Cheng HP, Ren J, Gao F*. Aerobic Exercise Sensitizes Myocardial Contractile Response to Insulin: Role of Akt-Dependent eNOS activation. Cardiovasc Res 2007; 75: 369-80.
5. Su H, Sun Xin, Ma H, Zhang HF, Yu QJ, Huang C, Wang XM, Luan RH, Jia GL, Wang HC, Gao F*. Acute hyperglycemia exacerbates myocardial ischemia /reperfusion injury and blunts cardioprotective effect of GIK. Am J Physiol- Endocrinol Metab 2007; 293:E629-35.
6. Zhang KR, Liu HT, Zhang HF, Zhang QJ, Li QX, Yu QJ, Guo WY, Wang HC, Gao F*. Long term aerobic exercise protects the heart against ischemia/reperfusion injury via PI3 kinase-dependent and Akt-mediated mechanism. Apoptosis 2007; 12:1579-88.
7. Ma H, Zhang HF, Zhang QJ, Huo JH, Dong L, Li J, Wang YM, Wang HC, Guo WY, Su H, Gao F*. Vasculoprotective effect of insulin in the ischemic/reperfused canine heart: Role of Akt-stimulated NO production. Cardiovasc Res 2006; 69: 57-65.
8. Zhang HF, Fan Q, Qian XX, Lopez BL, Christopher TA, Ma XL, Gao F*. Role of insulin in the antiapoptotic effect of glucose-insulin-potassium in rabbits with acute myocardial ischemia and reperfusion. Apoptosis 2004; 9:777-83.
9. Gao F*, Tao L, Yan WL, Gao E, Ma XL, Lopez BL, Christopher TA. Early Anti-Apoptosis Treatment Reduces Myocardial Infarct Size After A Prolonged Reperfusion. Apoptosis 2004; 9:553-59.
10. Gao F, Gao E, Yue TL, Ohlstein EH, Lopez BL, Christopher TA, Ma XL. Nitric oxide mediates the antiapoptotic effect of insulin in myocardial ischemia-reperfusion: the roles of PI3-kinase, Akt, and endothelial nitric oxide synthase phosphorylation. Circulation. 2002; 105: 1497-502.