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Dr. Hua HAN, an expert in molecular developmental biology, is supported by many projects dedicated to promoting outstanding young researchers, including National Science Fund for Distinguished Young Scholars (2003). He enjoys the government special allowance distributed by the State Council of China, and won the "Sliver Star" in Science and Technology by the PLA General Department of Logistics.

He is now the Director and Professor of Department of Medical Genetics and Developmental Biology, School of Preclinical Education, Fourth Military Medical University. He is a member of the Expert Evaluation Group for the Department of Life Science, NSFC and the Vice-Chairman of Shaanxi Association for Medical Genetics. In addition, he is a member of the Expert Evaluation Group for Science and Technology Programs of Shaanxi Province and an expert in Chinese 973 Program.

He is engaged in scientific research on molecular mechanism underlying mammalian development. His research has been supported by grants from national science fund for Distinguished Young Scholars, from the Plan to Develop Cheung Kong Scholar Program and Innovative Groups, from National High Technology Research and Development Program of China (973 Program) Fund, and from Program For Outstanding Talents Across Century and National Eleventh Five-year Plan to tackle key problems in science and technology.

He was awarded the first prize in Science and Technology Programs of Shaanxi Province in 2007, the third prize for  Chinese Medical Science and Technology Award in 2008 and one national patent in 2007. He has  published 40 papers in international peer-reviewed journals, including Nature Immunology, Immunity, Hepatology and Nucleic. Acid. Res.


Publications (selected):

1、Veno-occlusive disease and abnormal liver regeneration occur with disruption recombination signal-binding protein (RBP) in mice. Hepatology   (IF=10.7)

2、RBP-J, the transcription factor downstream of Notch receptors, is essential for the maintenance of vascular homeostasis in adult mice. FASEB J. (IF=6.72)

3、The transcriptional repression activity of KyoT2 on the Notch/RBP-J pathway is regulated by PIAS1-catalyzed SUMOylation. J. Mol. Biol. (IF=4.89)

4、Host defense against C. albicans infections in IgH transgenic mice with VH derived from a natural anti-keratin antibody. Cell. Microbiol. (IF=5.07)

5、Identification of CD36 as a new surface marker of marginal zone B cells by transcriptomic analysis. Mol. Immunol. (IF=4.76)

6、Mint represses transactivation of the type II collagen gene enhancer through interaction with aA -crystallin-binding protein 1. J. Biol. Chem. (IF=5.80)

7、RING1 inhibits transactivation of RBP-J by Notch through interaction with LIM protein KyoT2. Nucleic Acids Res. (IF=6.31)

8、Regulation of ab/gd T cell lineage commitment and peripheral T cell responses by Notch/RBP-J signaling. Immunity.(IF=18.30)

9、Regulation of marginal zone B cell development by MINT, a suppressor of Notch/RBP-J signaling pathway. Immunity. (IF=18.30)

10、Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cells. Nat. Immunol. (IF=27.50)

Fourth Military Medical University 
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